Home Search   - accession no   - plant   - pathogen   - molecule   - interaction Microarray expression  In silico expression analysis cis-elements Signaling pathways Description Documentation Contact Disclaimer	Reference RF000061   General Information Acc No  RF000061 Journal  Nature Authors  Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J. Title  MAP kinase signalling cascade in Arabidopsis innate immunity. Volume  415 Issue  6875 Page  977-83 Year  2002 Abstract  There is remarkable conservation in the recognition of pathogen-associated molecular patterns (PAMPs) by innate immune responses of plants, insects and mammals. We developed an Arabidopsis thaliana leaf cell system based on the induction of early-defence gene transcription by flagellin, a highly conserved component of bacterial flagella that functions as a PAMP in plants and mammals. Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a leucine-rich-repeat (LRR) receptor kinase. Activation of this MAPK cascade confers resistance to both bacterial and fungal pathogens, suggesting that signalling events initiated by diverse pathogens converge into a conserved MAPK cascade. PMID  11875555 Corresp Author  Sheen J Corresp Email  sheen@molbio.mgh.harvard.edu Creation  Oct 30 2002 05:11:13:980PM Creator  lb Last Update  Jan 24 2003 10:22:27:000AM Last Updater  lb Hyperlinks Database  Link  PubMed  11875555
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