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Reference RF000061
General Information
Acc No RF000061
Journal Nature
Authors Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J.
Title MAP kinase signalling cascade in Arabidopsis innate immunity.
Volume 415
Issue 6875
Page 977-83
Year 2002
Abstract There is remarkable conservation in the recognition of pathogen-associated molecular patterns (PAMPs) by innate immune responses of plants, insects and mammals. We developed an Arabidopsis thaliana leaf cell system based on the induction of early-defence gene transcription by flagellin, a highly conserved component of bacterial flagella that functions as a PAMP in plants and mammals. Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a leucine-rich-repeat (LRR) receptor kinase. Activation of this MAPK cascade confers resistance to both bacterial and fungal pathogens, suggesting that signalling events initiated by diverse pathogens converge into a conserved MAPK cascade.
PMID 11875555
Corresp Author Sheen J
Corresp Email
Creation Oct 30 2002 05:11:13:980PM
Creator lb
Last Update Jan 24 2003 10:22:27:000AM
Last Updater lb
Database  Link 
PubMed  11875555

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