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Reference RF000403
General Information
Acc No RF000403
Journal Cell
Authors Mackey D, Holt BF 3rd, Wiig A, Dangl JL.
Title RIN4 interacts with Pseudomonas syringae type III effector molecules and is required for RPM1-mediated resistance in Arabidopsis.
Volume 108
Issue 6
Page 743-54.
Year 2002
Abstract In Arabidopsis, RPM1 confers resistance against Pseudomonas syringae expressing either of two sequence unrelated type III effectors, AvrRpm1 or AvrB. An RPM1-interacting protein (RIN4) coimmunoprecipitates from plant cell extracts with AvrB, AvrRpm1, or RPM1. Reduction of RIN4 protein levels inhibits both the hypersensitive response and the restriction of pathogen growth controlled by RPM1. RIN4 reduction causes diminution of RPM1. RIN4 reduction results in heightened resistance to virulent Peronospora parasitica and P. syringae, and ectopic defense gene expression. Thus, RIN4 positively regulates RPM1-mediated resistance yet is, formally, a negative regulator of basal defense responses. AvrRpm1 and AvrB induce RIN4 phosphorylation. This may enhance RIN4 activity as a negative regulator of plant defense, facilitating pathogen growth. RPM1 may "guard" against pathogens that use AvrRpm1 and AvrB to manipulate RIN4 activity.
PMID 11955429
Corresp Author Mackey D, Holt BF 3rd, Wiig A, Dangl JL.
Corresp Email Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
Creation Nov 18 2010 01:58:38:937PM
Creator sp
Last Update Nov 18 2010 01:59:48:000PM
Last Updater sp
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PubMed  11955429

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