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Reference RF000424
 
General Information
Acc No RF000424
Journal Cell Host Microbe
Authors Shan L, He P, Li J, Heese A, Peck SC, N├╝rnberger T, Martin GB, Sheen J.
Title Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity.
Volume 4
Issue 1
Page 17-27.
Year 2008
Abstract Successful pathogens have evolved strategies to interfere with host immune systems. For example, the ubiquitous plant pathogen Pseudomonas syringae injects two sequence-distinct effectors, AvrPto and AvrPtoB, to intercept convergent innate immune responses stimulated by multiple microbe-associated molecular patterns (MAMPs). However, the direct host targets and precise molecular mechanisms of bacterial effectors remain largely obscure. We show that AvrPto and AvrPtoB bind the Arabidopsis receptor-like kinase BAK1, a shared signaling partner of both the flagellin receptor FLS2 and the brassinosteroid receptor BRI1. This targeting interferes with ligand-dependent association of FLS2 with BAK1 during infection. It also impedes BAK1-dependent host immune responses to diverse other MAMPs and brassinosteroid signaling. Significantly, the structural basis of AvrPto-BAK1 interaction appears to be distinct from AvrPto-Pto association required for effector-triggered immunity. These findings uncover a unique strategy of bacterial pathogenesis where virulence effectors block signal transmission through a key common component of multiple MAMP-receptor complexes.
PMID 18621007
Corresp Author Shan L, He P, Li J, Heese A, Peck SC, N├╝rnberger T, Martin GB, Sheen J.
Corresp Email Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Creation Dec 8 2010 01:42:52:107PM
Creator sp
Last Update Dec 8 2010 01:45:37:000PM
Last Updater sp
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PubMed  18621007

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