| Reference RF000061 |
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| Acc No | RF000061 | | Journal | Nature | | Authors | Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J. | | Title | MAP kinase signalling cascade in Arabidopsis innate immunity. | | Volume | 415 | | Issue | 6875 | | Page | 977-83 | | Year | 2002 | | Abstract | There is remarkable conservation in the recognition of pathogen-associated molecular patterns (PAMPs) by innate immune responses of plants, insects and mammals. We developed an Arabidopsis thaliana leaf cell system based on the induction of early-defence gene transcription by flagellin, a highly conserved component of bacterial flagella that functions as a PAMP in plants and mammals. Here we identify a complete plant MAP kinase cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) and WRKY22/WRKY29 transcription factors that function downstream of the flagellin receptor FLS2, a leucine-rich-repeat (LRR) receptor kinase. Activation of this MAPK cascade confers resistance to both bacterial and fungal pathogens, suggesting that signalling events initiated by diverse pathogens converge into a conserved MAPK cascade. | | PMID | 11875555 | | Corresp Author | Sheen J | | Corresp Email | sheen@molbio.mgh.harvard.edu | | Creation | Oct 30 2002 05:11:13:980PM | | Creator | lb | | Last Update | Jan 24 2003 10:22:27:000AM | | Last Updater | lb |
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