Reference RF000119   General Information Acc No  RF000119 Journal  Cell Authors  Hua J, Meyerowitz EM. Title  Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana. Volume  94 Issue  2 Page  261-71 Year  1998 Abstract  A family of genes including ETR1, ETR2, EIN4, ERS1, and ERS2 is implicated in ethylene perception in Arabidopsis thaliana. As only dominant mutations were previously available for these genes, it was unclear whether all of them are components in the ethylene signaling pathway and whether they code for positive or negative regulators of ethylene responses. In this study, we have isolated loss-of-function mutations of four of these genes (ETR1, ETR2, EIN4, and ERS2) and identified an ethylene-independent role of ETR1 in promoting cell elongation. Quadruple mutants had constitutive ethylene responses, revealing that these proteins negatively regulate ethylene responses and that the induction of ethylene response in Arabidopsis is through inactivation rather than activation of these proteins. PMID  9695954 Corresp Author  Meyerowitz EM Corresp Email  Meyerow@cco.caltech.edu Creation  Jan 13 2003 07:00:30:153PM Creator  lb Last Update  Jan 27 2003 04:21:15:000PM Last Updater  lb Hyperlinks Database  Link  PubMed  9695954