| Reference RF000462 |
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| Acc No | RF000462 | | Journal | Nature | | Authors | Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J. | | Title | Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling. | | Volume | 451 | | Issue | 7180 | | Page | 789-95. | | Year | 2008 | | Abstract | A principal question in MAP kinase (MAPK/MPK) cascade signalling is how similar components dictate different specificity in the information-processing machineries from yeast to humans and plants. In Arabidopsis, how MPK3/6 modulates distinct outputs in diverse signal transduction pathways remains elusive. By combining systematic cellular and genetic screens, here we uncover a previously unexpected MKK9-MPK3/MPK6 cascade promoting ethylene-insensitive 3 (EIN3)-mediated transcription in ethylene signalling. The mkk9 mutant exhibits a broad spectrum of moderate ethylene-insensitive phenotypes, and translocated MKK9 governs nuclear signalling downstream of receptors. Breaking a linear model and conventional MAPK signalling, ethylene inactivates the negative regulator constitutive triple response 1 (CTR1, a Raf-like MAPK kinase kinase (MAPKKK)) to activate the positive MKK9-MPK3/6 cascade. The bifurcate and antagonistic CTR1 and MKK9 pathways are both critical in determining ethylene-signalling specificity through two MAPK phosphorylation sites with opposite effects on EIN3 stability. The results suggest a new paradigm for linking intertwined MAPK cascades to control quantitative responses and specificity in signalling networks. | | PMID | 18273012 | | Corresp Author | Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J. | | Corresp Email | Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Med | | Creation | Feb 1 2011 02:49:55:810PM | | Creator | sp | | Last Update | Feb 1 2011 02:51:05:000PM | | Last Updater | sp |
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