Reference RF000462
General Information
Acc No RF000462
Journal Nature
Authors Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J.
Title Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling.
Volume 451
Issue 7180
Page 789-95.
Year 2008
Abstract A principal question in MAP kinase (MAPK/MPK) cascade signalling is how similar components dictate different specificity in the information-processing machineries from yeast to humans and plants. In Arabidopsis, how MPK3/6 modulates distinct outputs in diverse signal transduction pathways remains elusive. By combining systematic cellular and genetic screens, here we uncover a previously unexpected MKK9-MPK3/MPK6 cascade promoting ethylene-insensitive 3 (EIN3)-mediated transcription in ethylene signalling. The mkk9 mutant exhibits a broad spectrum of moderate ethylene-insensitive phenotypes, and translocated MKK9 governs nuclear signalling downstream of receptors. Breaking a linear model and conventional MAPK signalling, ethylene inactivates the negative regulator constitutive triple response 1 (CTR1, a Raf-like MAPK kinase kinase (MAPKKK)) to activate the positive MKK9-MPK3/6 cascade. The bifurcate and antagonistic CTR1 and MKK9 pathways are both critical in determining ethylene-signalling specificity through two MAPK phosphorylation sites with opposite effects on EIN3 stability. The results suggest a new paradigm for linking intertwined MAPK cascades to control quantitative responses and specificity in signalling networks.
PMID 18273012
Corresp Author Yoo SD, Cho YH, Tena G, Xiong Y, Sheen J.
Corresp Email Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Med
Creation Feb 1 2011 02:49:55:810PM
Creator sp
Last Update Feb 1 2011 02:51:05:000PM
Last Updater sp
Database  Link 
PubMed  18273012